|
KMID : 0616120060370040229
|
|
Korean Journal of Pharmacognosy
2006 Volume.37 No. 4 p.229 ~ p.234
|
|
|
The Inhibitory activity of the Taraxacum mongolicum on Monoamine oxidase
|
|
Hwang Keum-Hee
Park Tae-Kyu
|
|
|
Abstract
|
|
|
|
We examined the inhibitory activities against monoamine oxidase(MAO) of Taraxacum mongolicum in vitro and in vivo methods. Methanol extract of T. mongolicum showed significantly inhibitory activities on MAO-B that were prepared from rat brain and liver in vitro. MAO-A and MAO-B activities were potently inhibited by chloroform fraction of T. mongolicum in vitro tests. The IC50 values of each fraction on MAO-A are as followed; methanol extracts(0.90mg/ml), CHCl4 fraction (0.10mg/ml), EtOAc fraction(0.36mg/ml). and those on MAO-B are methanol extracts (0.39μg/ml), CHCl4 fraction (0.18μg/ml), BuOH fraction(0.22μg/ml). Those MAO-A and MAO-B activities in vivo tests have different tendency each other. MAO-A activitiy was increased by the oral administration of ethanol extract of T. mongolicum , while MAO-B activity was decreased. The concentration of serotonin of brain tissue after oral administration of ethanolic extract of T. mongolicum is slightly increased in rat. This tendency is not different from the activity of deprenyl which is the well-known MAO inhibitor used as a positive control. Based on these results, we can suggest that T. mongolicum may have the effects on the inhibitory activities against MAO. These activities of T. mongolicum is considerable for development of fuctional materials for the purpose of treatment and control of depressant, dementia, Parkinsin’ disease, stress and promoting exercise.
|
|
|
KEYWORD
|
|
|
monoamine oxidase (MAO), serotonin (5-HT), Taraxacum mongolicum
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|